Katherine Heigl

Branching out into television, Heigl co-starred with Peter Fonda in a Shakespeare-via-Civil War reworking of The Tempest (1998). Benefiting from the late-'90s wave of youth-driven TV shows, Heigl stayed with television and attracted an avid following as alien beauty Isabel on the cult hit Roswell. The doctors-in-love dramedy Grey's Anatomy, however, catapulted its entire cast to full-fledged stardom when it premiered in 2005; Heigl's role as the tough-cookie intern Izzie endeared her to countless fans of the show. The actress savvily parlayed this success into a movie career, although not by going the traditional three-hanky drama route. After winningly playing a Special Olympics counselor in 2005's broad comedy The Ringer, Heigl seemed the perfect choice for writer-director Judd Apatow's follow-up to The 40-Year-Old Virgin, 2007's Knocked Up. The improv-heavy tale of an unlikely one-night-stand - and its consequences - relied upon Heigl's charm and crack comedic timing to balance out the dude-centric humor supplied by co-stars Seth Rogen and Paul Rudd. The combination worked, as audiences made Knocked Up a bona-fide summer hit. ~ Lucia Bozzola, All Movie Guide