A pampered Chihuahua accustomed to the living the good life in glamorous Beverly Hills must rein in her heiress instincts and rely on the kindness of strangers in order to find her way back home after becoming hopelessly lost in Mexico. Chloe (voice of
Drew Barrymore) is a diamond-clad toy dog who favors traveling in her wealthy owner's purse over frolicking in an open park, and Papi (voice of
George Lopez) is the kind of independent pup that she doesn't afford a second glance. When a vacation mishap leaves Chloe stranded in Mexico, the Chihuahua who doesn't speak a lick of Spanish must rely on street-smart German shepherd Delgado (voice of
Andy Garcia) to guide her back home before she wanders any further south. Meanwhile, brave Papi races to the border intent on proving his love for Chloe by tracking her down and escorting her home in style. Along the way, Papi is joined by an enthusiastic pack of helpful pooches (voices of
Luis Guzman,
Plácido Domingo, and
Eddie "Piolin" Sotelo) a pair of concerned humans (
Piper Perabo and
Manolo Cardona), an anxious iguana (voice of
Paul Rodriguez), and a crafty rat (voice of
Cheech Marin). ~ Jason Buchanan, All Movie Guide