| 2005 | Best Director (Runner-up) (winner) | Los Angeles Film Critics Association | David Cronenberg |
| 2005 | Best Performance by an Actor in a Supporting Role in a Motion Pic (winner) | Los Angeles Film Critics Association | William Hurt |
| 2005 | Best Supporting Actress (nominee) | Broadcast Film Critics Association | Maria Bello |
| 2005 | Best Performance by an Actress in a Motion Picture - Drama (nominee) | Golden Globe | Maria Bello |
| 2005 | Best Actress (nominee) | London Film Critics Association | Maria Bello |
| 2005 | Best Actor (nominee) | London Film Critics Association | Viggo Mortensen |
| 2005 | Best Director (nominee) | London Film Critics Association | David Cronenberg |
| 2005 | Best Director (winner) | Chicago Film Critics Association | David Cronenberg |
| 2005 | Best Screenplay (nominee) | Chicago Film Critics Association | Josh Olson |
| 2005 | Best Supporting Actress (winner) | Chicago Film Critics Association | Maria Bello |
| 2005 | Best Adapted Screenplay (nominee) | Writers Guild of America | Josh Olson |
| 2005 | Best Supporting Actress (nominee) | Kansas City Film Critics Association | Maria Bello |
| 2005 | Best Director (nominee) | Toronto Film Critics Association | David Cronenberg |
| 2005 | Best Director (winner) | National Society of Film Critics | David Cronenberg |
| 2005 | Best Supporting Actor (winner) | National Society of Film Critics | Ed Harris |
| 2005 | Best Director (winner) | Online Film Critics Association | David Cronenberg |
| 2005 | Best Performance by an Actor in a Supporting Role in a Motion Pic (nominee) | Online Film Critics Association | William Hurt |
| 2005 | Best Supporting Actress (winner) | Online Film Critics Association | Maria Bello |
| 2005 | Best Adapted Screenplay (nominee) | Online Film Critics Association | Josh Olson |
| 2005 | Best Editing (nominee) | Online Film Critics Association | Ronald Sanders |
| 2005 | Best Adapted Screenplay (nominee) | British Academy of Film and Television | Josh Olson |
| 2005 | Best Performance by an Actor in a Supporting Role in a Motion Pic (nominee) | Academy of Motion Picture Arts and Scie | William Hurt |
| 2005 | Best Adapted Screenplay (nominee) | Academy of Motion Picture Arts and Scie | Josh Olson |
| 2005 | Best Performance by an Actor in a Supporting Role in a Motion Pic (winner) | New York Film Critics Circle | William Hurt |
| 2005 | Best Supporting Actress (winner) | New York Film Critics Circle | Maria Bello |